Chronic Ethanol Administration causes oxidative stress in the rat pancreas

There is increasing evidence implicating oxidative stress in the pathogenesis of both acute and chronic pancreatitis. Because ethanol is a major cause of pancreatitis in Western society, the aim was to determine wether chronic ethanol administration results in oxidative stress in the pancreas.

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The drinker’s pancreas: Molecular Mechanisms Emerge

The pathogenesis of alcoholic pancreatitis has perplexed pancreatologists ever since Friedreich’s description of ‘the drunkard pancreas’ in 1878.

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Both Ethanol and protein deficiency increase messenger RNA levels for pancreatic lithostathine

Both ethanol abuse and protein deficiency are well known associations of chronic pancreatitis. An early event in chronic pancreatitis is the deposition of protein plugs in small pancreatic ducts, leading to ductular obstruction and acinar cell damage.

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Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

Pancreatic stellate cells (PSC) produce the stromal reaction in pancreatic cancer, but their role in cancer progression is not fully elucidated.

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Pancreatic Stellate Cells and Pancreatic Cancer Cells: An Unholy Alliance

Pancreatic cancer—a tumor displaying a particularly abundant stromal reaction—is notorious for its poor prognosis. Recent studies, via newly developed orthotopic models, provide compelling evidence of an important role for pancreatic stellate cells (PSC) in pancreatic cancer progression.

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Malnutrition as a cause of chronic pancreatitis: Myth dispelled?

A role for protein energy malnutrition in the etiopathogenesis of chronic pancreatitis was postulated several decades ago, based largely on studies of tropical pancreatitis (a chronic calcifying form of pancreatitis) occurring in non-alcoholics from areas where malnutrition is prevalent, such as India, South-East Asia and some parts of Africa.

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Alcoholic Pancreatitis and Polymorphisms of the Variable Length Polythymidine Tract in the Cystic Fibrosis Gene

The observation that only a minority of alcoholics develops clinical pancreatic disease has led to a search for predisposing factor to the disease.

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Pancreatic Disease

The pancreas is both an endocrine and an exocrine gland. We focus here on the common diseases of the exocrine pancreas – pancreatitis and pancreatic cancer.

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Non-Oxidative Metabolism of Ethanol by Rat Pancreatic Acini

The pathogenesis of alcohol pancreatitis may involve the metabolism of ethanol (via oxidative and non-oxidative pathways) within the pancreas. The aims of this study were to determine the rate of non-oxidative metabolism in isolated rat pancreatic acini and to compare this to the rate of ethanol oxidation.

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New insights into alcoholic pancreatitis and pancreatic cancer

Pancreatitis and pancreatic cancer represent two major diseases of the exocrine pancreas. Pancreatitis exhibits both acute and chronic manifestations. The commonest causes of acute pancreatitis are gallstones and alcohol abuse; the latter is also the predominant cause of chronic pancreatitis.

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