Activation of Pancreatic Stellate Cells in Human and Experimental Pancreatic Fibrosis

Paul S. Haber,* Gregory W. Keogh,† Minoti V. Apte,* Corey S. Moran,* Nancy L. Stewart,‡ Darrell H.G. Crawford,‡ Romano C. Pirola,* Geoffrey W. McCaughan,* Grant A. Ramm,‡ and Jeremy S. Wilson* From the Departments of Gastroenterology * and Surgery,† Pancreatic Research Group, Prince of Wales Hospital, University of New South Wales, Sydney; and the Department of Medicine,‡ Hepatic Fibrosis Group, Clinical Sciences Unit, Queensland, Institute of Medical Research and the University of Queensland Brisbane, Australia

The mechanisms of pancreatic fibrosis are poorly understood. In the liver, stellate cells play an important role in fibrogenesis. Similar cells have recently been isolated from the pancreas and are termed pancreatic stellate cells. The aim of this study was to determine whether pancreatic stellate cell activation occurs during experimental and human pancreatic

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