Impact of Complete Inhibition of Viral Replication on the Cellular Immune Response in Chronic Hepatitis B Virus Infection

Interferon alfa (IFN-a) treatment is effective in only a proportion of patients with chronic hepatitis B virus (HBV) infection. The mechanisms for therapeutic failure remain unknown but high levels of HBV replication are known to inhibit the immunopotentiating effects of IFN-a.

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