Interleukin-12 Induction of Th1 Cytokines Is Important for Viral Clearance in Chronic Hepatitis B

Interleukin-12, a cytokine with an important role against intracellular pathogens, promotes Th1 cell development, cellmediated cytotoxicity, and interferong production. We investigated the immunoregulatory role of IL-12 in 72 chronic hepatitis B virus (HBV) carriers, 33 of whom were monitored longitudinally during interferon α treatment.

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